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Our work contributes to the growing body of research exploring protein homeostasis, aging, and cellular health.
2026
Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function
  • Scharping NE, Ge X, Matias MI, Jiang F, Cafferata A, Heeg M, Monell A, Galletti G, Cheung KP, Rock A, Thao N, Shuttleworth SL, Bauer MA, Takehara KK, Ferry A, Quon S, Koss B, Myers SA, Bennett EJ, Goldrath AW.
  • Cell. 2026 Apr 29:S0092-8674(26)00226-6. doi: 10.1016/j.cell.2026.02.019.
  • PMID: 42061400
ExoSloNano: multimodal nanogold labels for identification of macromolecules in live cells and cryo-electron tomograms
  • Young LN, Sherrard A, Zhou H, Shaikh F, Hutchings J, Riggi M, Narasimhan M, Flaherty WA, Bennett EJ, Rosen MK, Giraldez AJ, Villa E.
  • Nat Methods. 2026 Jan;23(1):131-142. doi: 10.1038/s41592-025-02928-4. Epub 2025 Nov 28.
  • PMID: 41315814
The proteostasis network is a therapeutic target in acute myeloid leukemia
  • Lam K, Kim YJ, Tan EL, Ong CM, Liu AZ, Zhou FJ, Sunshine MJ, Chua BA, Vicenzi S, Chen K, Yu H, Ford PW, Zhou JH, Hong Y, Bennett EJ, Crews LA, Ball ED, Signer RAJ.
  • Blood. 2026 Jan 29;147(5):557-572. doi: 10.1182/blood.2024026749.
  • PMID: 41111393
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
  • Rhine K, Li R, Kopalle HM, Rothamel K, Ge X, Epstein E, Mizrahi O, Madrigal AA, Her HL, Gomberg TA, Hermann A, Schwartz JL, Daniels AJ, Manor U, Ravits J, Signer RAJ, Bennett EJ, Yeo GW.
  • Nat Neurosci. 2025 Jun;28(6):1174-1184. doi: 10.1038/s41593-025-01952-z. Epub 2025 Jun 2.
  • PMID: 40456907
Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor
  • Nicholson-Shaw T, Dowdle ME, Ajaj Y, Perelis M, Fulzele A, Yeo GW, Bennett EJ, Lykke-Andersen J.
  • RNA. 2025 Jul 16;31(8):1195-1205. doi: 10.1261/rna.080399.125.
  • PMID: 40441874
Employing Expression-Matched Controls Enables High-Confidence Proximity-Based Interactome Classification
  • Jiang F, Ge X, Bennett EJ.
  • Mol Cell Proteomics. 2025 Jul;24(7):101001
  • PMID: 40441440
RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation
  • Ford PW, Garshott DM, Narasimhan M, Ge X, Jordahl EM, Subramanya S, Bennett EJ.
  • Cell Rep. 2025 Mar 25;44(3):115371. doi: 10.1016/j.celrep.2025.115371. Epub 2025 Feb 28.
  • PMID: 40022732
Ubiquitin-dependent translation control mechanisms: Degradation and beyond
  • Ford PW, Narasimhan M, Bennett EJ.
  • Cell Rep. 2024 Dec 24;43(12):115050. doi: 10.1016/j.celrep.2024.115050. Epub 2024 Dec 10.
  • PMID: 396615187
How degrading! Trapped translation factors get trashed
  • Ford PW, Bennett EJ. Cell Rep. 2023 Nov 28;42(11):113278. doi: 10.1016/j.celrep.2023.113278.
  • PMID: 37910507
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
  • Monda JK, Ge X, Hunkeler M, Donovan KA, Ma MW, Jin CY, Leonard M, Fischer ES, Bennett EJ.
  • Cell Rep. 2023 May 9;42(5):112496. doi: 10.1016/j.celrep.2023.112496. PMID: 37167062
The OPAQUE1/DISCORDIA2 myosin XI is required for phragmoplast guidance during asymmetric cell division in maize
  • Nan Q, Liang H, Mendoza J, Liu L, Fulzele A, Wright A, Bennett EJ, Rasmussen CG, Facette MR.
  • Plant Cell. 2023 Apr 5:koad099. doi: 10.1093/plcell/koad099. PMID: 37017144
Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis
  • Chua BA, Lennan CJ, Sunshine MJ, Dreifke D, Chawla A, Bennett EJ, Signer RAJ.
  • Cell Stem Cell. 2023 Apr 6;30(4):460-472.e6. doi: 10.1016/j.stem.2023.02.010. Epub 2023 Mar 21. PMID: 36948186
An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
  • Bhaduri S, Aguayo A, Ohno Y, Proietto M, Jung J, Wang I, Kandel R, Singh N, Ibrahim I, Fulzele A, Bennett EJ, Kihara A, Neal SE.
  • EMBO J. 2023 Feb 15;42(4):e112275. doi: 10.15252/embj.2022112275. Epub 2022 Nov 9. PMID: 36350249
Polarly localized WPR proteins interact with PAN receptors and the actin cytoskeleton during maize stomatal development
  • Nan Q, Char SN, Yang B, Bennett EJ, Yang B, Facette MR.
  • Plant Cell. 2023 Jan 2;35(1):469-487. doi: 10.1093/plcell/koac301. PMID: 36227066
Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
  • Banta KL, Xu X, Chitre AS, Au-Yeung A, Takahashi C, O’Gorman WE, Wu TD, Mittman S, Cubas R, Comps-Agrar L, Fulzele A, Bennett EJ, Grogan JL, Hui E, Chiang EY, Mellman I.
  • Immunity. 2022 Mar 8;55(3):512-526.e9. doi: 10.1016/j.immuni.2022.02.005. PMID: 35263569
Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report
  • Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, Chang C, Ge L, Schulman BA, Deshaies RJ, Dikic I, Harper JW, Wertz IE, Thomä NH, Słabicki M, Frydman J, Jakob U, David DC, Bennett EJ, Bertozzi CR, Sardana R, Eapen VV, Carra S.
  • Ann N Y Acad Sci. 2022 Apr;1510(1):79-99. doi: 10.1111/nyas.14745. Epub 2022 Jan 8. PMID: 35000205
iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation
  • Garshott DM, An H, Sundaramoorthy E, Leonard M, Vicary A, Harper JW, Bennett EJ.
  • Cell Rep. 2021 Aug 31;36(9):109642. doi: 10.1016/j.celrep.2021.109642.PMID: 34469731
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
  • Markmiller S, Sathe S, Server KL, Nguyen TB, Fulzele A, Cody N, Javaherian A, Broski S, Finkbeiner S, Bennett EJ, Lécuyer E, Yeo GW.
  • Cell Rep. 2021 Sep 7;36(10):109685. doi: 10.1016/j.celrep.2021.109685. PMID: 34496257
Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition
  • Hunkeler M, Jin CY, Ma MW, Monda JK, Overwijn D, Bennett EJ, Fischer ES.
  • Mol Cell. 2021 Jul 16:S1097-2765(21)00543-8. doi: 10.1016/j.molcel.2021.06.032. PMID: 34314700
Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection
  • Sundaramoorthy E, Ryan AP, Fulzele A, Leonard M, Daugherty MD, Bennett EJ.
  • J Cell Sci. 2021 Apr 15;134(8):jcs257188. doi: 10.1242/jcs.257188. Epub 2021 Apr 28. PMID: 33912921
EDF1 coordinates cellular responses to ribosome collisions
  • Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper W, Bennett EJ, Beckmann R, Green R.
  • Elife. 2020 Aug 3;9:e58828. PMID: 32744497
Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA-Protein Interactions
  • Busby KN, Fulzele A, Zhang D, Bennett EJ, Devaraj NK.
  • ACS Chem Biol. 2020 Aug 10. PMID: 32706237
PD-1 and BTLA Regulate T Cell Signaling Differentially and Only Partially Through SHP1 and SHP2
  • Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E.
  • J Cell Biol. 2020 Jun 1;219(6) PMID: 32437509
A cullin-RING Ubiquitin Ligase Promotes Thermotolerance as Part of the Intracellular Pathogen Response in Caenorhabditis elegans
  • Panek J, Gang SS, Reddy KC, Luallen RJ, Fulzele A, Bennett EJ, Troemel ER. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7950-7960. PMID: 32193347
Distinct Regulatory Ribosomal Ubiquitylation Events Are Reversible and Hierarchically Organized
  • Garshott DM, Sundaramoorthy E, Leonard M, Bennett EJ. Elife, 9 2020 Feb 3. PMID: 32011234
Bombardier Enables Delivery of Short-Form Bomanins in the Drosophila Toll Response
  • Lin SJH, Fulzele A, Cohen LB, Bennett EJ, Wasserman SA. Front Immunol, 10, 3040 2020 Jan 10. PMID: 31998316
Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics
  • Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo GW, Bennett EJ.
  • Cell Rep. 2019 Apr 30;27(5):1356-1363.e3. PMID:31042464
Ubiquitin diGLY Proteomics as an Approach to Identify and Quantify the Ubiquitin-Modified Proteome
  • Fulzele A, Bennett EJ.
  • Methods Mol Biol. 2018;1844:363-384. PMID: 30242721
USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis
  • Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT.
  • Mol Cancer Res. 2018 Jul;16(7):1172-1184. PMID: 29724812
Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins
  • Lee CM, Feke A, Li MW, Adamchek C, Webb K, Pruneda-Paz J, Bennett EJ, Kay SA, Gendron JM.
  • Plant Physiol. 2018 Jul;177(3):1170-1186. PMID: 29794020
Mapping the Mammalian Ribosome Quality Control Complex Interactome using Proximity Labeling Approaches
  • Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett EJ.
  • Mol Biol Cell. 2018 Mar 14. PMID: 29540532
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
  • Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW.
  • Cell. 2018 Jan 25;172(3):590-604. PMID: 29373831
Site-specific identification and quantitation of endogenous SUMO modifications under native conditions
  • Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA.
  • Nat Commun. 2017 Oct 27;8(1):1171.
  • PMID: 29079793
In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans
  • Reinke AW, Mak R, Troemel ER, Bennett EJ.
  • Sci Adv. 2017 May 10;3(5)
  • PMID: 28508060
ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation
  • Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ.
  • Mol Cell. 2017 Feb 16;65(4):751-760.
  • PMID: 28132843
Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing
  • Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çağlayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG.
  • Nat Genet. 2017 Jan 16.
  • PMID: 28092684
A “Retrochaperone” Function for Cdc48: the Cdc48 Complex is Required for Retrotranslocated ERAD-M Substrate Solubility
  • Neal SE, Mak R, Bennett EJ, Hampton R.
  • J Biol Chem. 2017 Jan 11.
  • PMID: 28077573
Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins
  • Reinke AW, Balla KM, Bennett EJ, Troemel ER.
  • Nat Commun. 2017 Jan 9;8:14023.
  • PMID: 28067236
Proteome complexity and the forces that drive proteome imbalance
  • Harper JW, Bennett EJ.
  • Nature. 2016 Sep 14;537(7620):328-38.
  • PMID: 27629639
The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation
  • Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J.
  • Mol Cell Biol. 2016 Aug 12;36(17):2226-35. doi: 10.1128/MCB.01102-15. Print 2016 Sep 1.
  • PMID: 27247266
Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction
  • Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ.
  • Mol Cell Proteomics. 2016 Aug;15(8):2576-93. doi: 10.1074/mcp.M116.058420. Epub 2016 May 16.
  • PMID: 27185884
Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements
  • Fu R, Olsen MT, Webb K, Bennett EJ, Lykke-Andersen J.
  • RNA. 2016 Jan 13
A competition between decapping complex formation and ubiquitin-mediated proteasomal degradation controls human Dcp2 decapping activity
  • Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J.
  • Mol Cell Biol. 2015 Apr 13. pii: MCB.01517-14.
  • PMID: 25870104
The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize
  • Facette MR, Park Y, Sutimantanapi D, Luo A, Cartwright HN, Yang B, Bennett EJ, Sylvester AW, Smith LG
  • Nature Plants 1, Article number: 14024 (2015) ?doi:10.1038/nplants.2014.24
  • Published online 26 January 2015
The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins
  • Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ.
  • Mol Cell. 2015 Jun 3
  • PMID: 26051182
Protecting the proteome: Eukaryotic cotranslational quality control pathways
  • Lykke-Andersen J, Bennett EJ.
  • J Cell Biol. 2014 Feb 17;204(4):467-76.
  • PMID: 24535822
TIF1gamma Regulates Epithelial Mesenchymal Transition by Operating as a SUMO E3 Ligase for theTranscriptional Regulator SnoN1
  • Ikeuchi Y, Dadakhujaev S, Chandhoke AS, Huynh MA, Oldenborg A, Ikeuchi M, Deng L, Bennett EJ, Harper JW, Bonni A, Bonni S.
  • J Biol Chem. 2014 Jul 24.
  • PMID: 25059663
Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex
  • Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA.
  • Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15981-6.
  • PMID: 25349383
Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails
  • Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G.
  • J Biol Chem. 2013 Nov 29;288(48):34882-96
  • PMID: 24129577
Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF(FBXL17) in NRF2 Activation via BACH1 Repressor Turnover
  • Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.
  • Mol Cell. 2013 Oct 10;52(1):9-24.
  • PMID: 24035498
The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain
  • Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, Bonni A.
  • Neuron. 2013 Jun 19;78(6):986-93.
  • PMID: 23791194
Using the ubiquitin modified proteome to monitor protein homeostasis function
  • Carrano AC, Bennett EJ.
  • Mol Cell Proteomics. 2013 May 23. [Epub ahead of print]
  • PMID: 23704779
Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes
  • Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA.
  • Structure. 2013 Jan 8;21(1):42-53.
  • PMID: 23201271
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
  • Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA.
  • Mol Cell Biol. 2013 Apr;33(8):1487-502.
  • PMID: 23382074
Proteomics propels protein degradation studies in San Diego
  • Bennett EJ, Mayor T.
  • Mol Cell Proteomics. 2012 Dec;11(12):1523-8.
  • PMID: 22798279
Systematic and quantitative assessment of the ubiquitin modified proteome
  • Kim, W.,* Bennett, E.J.*, Huttlin, E.L., Guo, A., Li, J., Possemato, A., Sowa, M.E., Rad, R., Rush, J., Comb, M.J., Harper, J.W., and Gygi, S.P. Molecular Cell 2011 Oct 21;44(2):325-40.
  • PMID: 21906983
  • * Authors contributed equally
N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex
  • Scott, D.C., Monda, J.K., Bennett, E.J., Harper, J.W., Schulman, B.A.
  • Science 2011 Nov 4;334(6056): 674-8.
  • PMID: 21940857
Defining human ERAD networks through an integrative mapping strategy
  • Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Wade Harper J, Kopito RR.
  • Nat Cell Biol. 2011 Nov 27. doi: 10.1038/ncb2383.
  • PMID: 22119785
Dynamics of cullin-RING ubiquitin ligase assembly revealed by systematic quantitative proteomics
  • Bennett EJ, Rush J, Gygi SP, Harper JW.
  • Cell 2010 Dec 10;143(6):951-65.
  • PMID: 21145461
A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain
  • Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A.
  • J Neurosci. 2013 Nov 13;33(46):18015-21.
  • PMID: 24227713
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