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Leveraging Proteostasis Mechanisms to Promote Healthy Aging

The Bennett Lab studies the fundamental principles of how cells build, maintain, and destroy proteins. Our research aims to define mechanisms that can be leveraged to promote healthy aging and combat human aging-associated disorders.

About The Bennett Lab

The Bennett research group aims to identify pathways and cellular factors that can be targeted to predictably impact proteostasis function to both exacerbate and diminish steady-state and stress-induced proteostasis capacity.
The research group utilizes integrated molecular, genetic, and systems-level approaches to examine mechanisms that catalyze proteome remodeling. We employ global and quantitative proteomic platforms that enable systematic analyses of protein homeostasis. These platforms enable studies aimed at detailing how the proteome responds to both genetic and environmental challenges to proteostasis.

Research Directions

Proteostasis Regulation

Understanding how cells regulate the synthesis, folding, and degradation of proteins to maintain cellular health.

Cellular Stress Responses

Exploring how cells respond to stress conditions to alter cellular stress resilience.

Proteostasis Network and Aging

We apply global and molecular approaches to manipulate the proteostasis network to improve tissue function during aging.

Ubiquitin Biology

Identifying and characterizing ubiquitin-dependent mechanisms that regulate cellular quality control pathways

Recent Publications

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

Scharping NE, Ge X, Matias MI, Jiang F, Cafferata A, Heeg M, Monell A, Galletti G, Cheung KP, Rock A, Thao N, Shuttleworth SL, Bauer MA, Takehara KK, Ferry A, Quon S, Koss B, Myers SA, Bennett EJ, Goldrath AW.
Cell. 2026 Apr 29:S0092-8674(26)00226-6. doi: 10.1016/j.cell.2026.02.019.
PMID: 42061400

Employing Expression-Matched Controls Enables High-Confidence Proximity-Based Interactome Classification

Jiang F, Ge X, Bennett EJ.
Mol Cell Proteomics. 2025 Jul;24(7):101001. doi: 10.1016/j.mcpro.2025.101001.
PMID: 40441440

Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress

Rhine K, Li R, Kopalle HM, Rothamel K, Ge X, Epstein E, Mizrahi O, Madrigal AA, Her HL, Gomberg TA, Hermann A, Schwartz JL, Daniels AJ, Manor U, Ravits J, Signer RAJ, Bennett EJ, Yeo GW.

Nat Neurosci. 2025 Jun;28(6):1174-1184. doi: 10.1038/s41593-025-01952-z. Epub 2025 Jun 2.

PMID: 40456907

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Meet the Research Team

The Bennett Lab brings together scientists, researchers, and students
who share a passion for understanding the molecular mechanisms of
aging and cellular biology. Our team collaborates across disciplines to
push the boundaries of scientific discovery.

View Full Team

Inside the Lab

Take a closer look at our research environment, laboratory activities, and collaborative projects. Our gallery highlights the work, people, and moments that drive scientific discovery in the Bennett Lab.

A collaborative study with the Goldrath Lab investigating T-cell proteostasis is published
  • Fun collaboration with our favorite T-cell experts. Nicole’s tour de force establishes that terminally exhausted tumor-infiltrating lymphocytes have reduced expression of three key ubiquitin ligases and signatures of proteostasis dysfunction.
  • Xuezhen and Fulin spearheaded some truly stunning deep proteomics from in vivo isolated T-cell populations. Congrats to everyone involved.
AJ presents her research at the 2026 Keystone Hematopoiesis conference

AJ's abstract was selected for a short talk!!

Collaborative study with the Lykke-Andersen lab selected for prize in RNA Journal
  • Congrats to Tim and all the authors that participated in this study.

Join Our Research Team

The Bennett Lab welcomes motivated students and researchers interested in exploring the biology of aging and protein homeostasis. We offer opportunities for graduate students, postdoctoral fellows, and collaborators who are passionate about advancing scientific knowledge.
Explore Opportunities

Get in Touch

If you are interested in collaborating, joining the lab, or learning more about our research, we would be happy to hear from you.
Email

e1bennett@ucsd.edu

Research Collaboration Inquiries

We welcome partnerships with academic and industry researchers.

Student and Postdoc Opportunities

Reach out to learn about open positions in our lab.

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