Ribosome quality control activity potentiates vaccinia virus protein synthesis during infection
Sundaramoorthy E, Ryan AP, Fulzele A, Leonard M, Daugherty MD, Bennett EJ.
J Cell Sci. 2021 Apr 15;134(8):jcs257188. doi: 10.1242/jcs.257188. Epub 2021 Apr 28. PMID: 33912921


EDF1 coordinates cellular responses to ribosome collisions
Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper W, Bennett EJ, Beckmann R, Green R.
Elife. 2020 Aug 3;9:e58828. PMID: 32744497

Enzymatic RNA Biotinylation for Affinity Purification and Identification of RNA-Protein Interactions
Busby KN, Fulzele A, Zhang D, Bennett EJ, Devaraj NK.
ACS Chem Biol. 2020 Aug 10. PMID: 32706237

PD-1 and BTLA Regulate T Cell Signaling Differentially and Only Partially Through SHP1 and SHP2
Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E.
J Cell Biol. 2020 Jun 1;219(6) PMID: 32437509

A cullin-RING Ubiquitin Ligase Promotes Thermotolerance as Part of the Intracellular Pathogen Response in Caenorhabditis elegans
Panek J, Gang SS, Reddy KC, Luallen RJ, Fulzele A, Bennett EJ, Troemel ER. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7950-7960. PMID: 32193347

Distinct Regulatory Ribosomal Ubiquitylation Events Are Reversible and Hierarchically Organized
Garshott DM, Sundaramoorthy E, Leonard M, Bennett EJ. Elife, 9 2020 Feb 3. PMID: 32011234

Bombardier Enables Delivery of Short-Form Bomanins in the Drosophila Toll Response
Lin SJH, Fulzele A, Cohen LB, Bennett EJ, Wasserman SA. Front Immunol, 10, 3040 2020 Jan 10. PMID: 31998316


Active Protein Neddylation or Ubiquitylation Is Dispensable for Stress Granule Dynamics.
Markmiller S, Fulzele A, Higgins R, Leonard M, Yeo GW, Bennett EJ.
Cell Rep. 2019 Apr 30;27(5):1356-1363.e3. PMID:31042464


Ubiquitin diGLY Proteomics as an Approach to Identify and Quantify the Ubiquitin-Modified Proteome.
Fulzele A, Bennett EJ.
Methods Mol Biol. 2018;1844:363-384. PMID: 30242721

USP11 Enhances TGFβ-Induced Epithelial-Mesenchymal Plasticity and Human Breast Cancer Metastasis.
Garcia DA, Baek C, Estrada MV, Tysl T, Bennett EJ, Yang J, Chang JT.
Mol Cancer Res. 2018 Jul;16(7):1172-1184. PMID: 29724812

Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.
Lee CM, Feke A, Li MW, Adamchek C, Webb K, Pruneda-Paz J, Bennett EJ, Kay SA, Gendron JM.
Plant Physiol. 2018 Jul;177(3):1170-1186. PMID: 29794020

Mapping the Mammalian Ribosome Quality Control Complex Interactome using Proximity Labeling Approaches
Zuzow N, Ghosh A, Leonard M, Liao J, Yang B, Bennett EJ.
Mol Biol Cell. 2018 Mar 14.  PMID: 29540532

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules.
Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW.
Cell. 2018 Jan 25;172(3):590-604. PMID: 29373831


Site-specific identification and quantitation of endogenous SUMO modifications under native conditions.
Lumpkin RJ, Gu H, Zhu Y, Leonard M, Ahmad AS, Clauser KR, Meyer JG, Bennett EJ, Komives EA.
Nat Commun. 2017 Oct 27;8(1):1171.
PMID: 29079793

In vivo mapping of tissue- and subcellular-specific proteomes in Caenorhabditis elegans.
Reinke AW, Mak R, Troemel ER, Bennett EJ.
Sci Adv. 2017 May 10;3(5)
PMID: 28508060

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation.
Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ.
Mol Cell. 2017 Feb 16;65(4):751-760.
PMID: 28132843

Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.
Lardelli RM, Schaffer AE, Eggens VR, Zaki MS, Grainger S, Sathe S, Van Nostrand EL, Schlachetzki Z, Rosti B, Akizu N, Scott E, Silhavy JL, Heckman LD, Rosti RO, Dikoglu E, Gregor A, Guemez-Gamboa A, Musaev D, Mande R, Widjaja A, Shaw TL, Markmiller S, Marin-Valencia I, Davies JH, de Meirleir L, Kayserili H, Altunoglu U, Freckmann ML, Warwick L, Chitayat D, Blaser S, Çağlayan AO, Bilguvar K, Per H, Fagerberg C, Christesen HT, Kibaek M, Aldinger KA, Manchester D, Matsumoto N, Muramatsu K, Saitsu H, Shiina M, Ogata K, Foulds N, Dobyns WB, Chi NC, Traver D, Spaccini L, Bova SM, Gabriel SB, Gunel M, Valente EM, Nassogne MC, Bennett EJ, Yeo GW, Baas F, Lykke-Andersen J, Gleeson JG.
Nat Genet. 2017 Jan 16.
PMID: 28092684

A “Retrochaperone” Function for Cdc48: the Cdc48 Complex is Required for Retrotranslocated ERAD-M Substrate Solubility.
Neal SE, Mak R, Bennett EJ, Hampton R.
J Biol Chem. 2017 Jan 11.
PMID: 28077573

Identification of microsporidia host-exposed proteins reveals a repertoire of rapidly evolving proteins.
Reinke AW, Balla KM, Bennett EJ, Troemel ER.
Nat Commun. 2017 Jan 9;8:14023.
PMID: 28067236


Proteome complexity and the forces that drive proteome imbalance.
Harper JW, Bennett EJ.
Nature. 2016 Sep 14;537(7620):328-38.
PMID: 27629639

The C-Terminal RGG Domain of Human Lsm4 Promotes Processing Body Formation Stimulated by Arginine Dimethylation.
Arribas-Layton M, Dennis J, Bennett EJ, Damgaard CK, Lykke-Andersen J.
Mol Cell Biol. 2016 Aug 12;36(17):2226-35. doi: 10.1128/MCB.01102-15. Print 2016 Sep 1.
PMID: 27247266

Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction.
Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ.
Mol Cell Proteomics. 2016 Aug;15(8):2576-93. doi: 10.1074/mcp.M116.058420. Epub 2016 May 16.
PMID: 27185884


A competition between decapping complex formation and ubiquitin-mediated proteasomal degradation controls human Dcp2 decapping activity.
Erickson SL, Corpuz EO, Maloy JP, Fillman C, Webb K, Bennett EJ, Lykke-Andersen J.
Mol Cell Biol. 2015 Apr 13. pii: MCB.01517-14.
PMID: 25870104

The SCAR/WAVE complex polarizes PAN receptors and promotes division asymmetry in maize.
Facette MR, Park Y, Sutimantanapi D, Luo A, Cartwright HN, Yang B, Bennett EJ, Sylvester AW, Smith LG
Nature Plants 1, Article number: 14024 (2015) ?doi:10.1038/nplants.2014.24
Published online 26 January 2015

UnfoldedProteinThe Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins.
Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, Bennett EJ.
Mol Cell. 2015 Jun 3
PMID: 26051182


6_10_15_bennett_lab_webpage_update003007Protecting the proteome: Eukaryotic cotranslational quality control pathways.
Lykke-Andersen J, Bennett EJ.
J Cell Biol. 2014 Feb 17;204(4):467-76.
PMID: 24535822

TIF1gamma Regulates Epithelial Mesenchymal Transition by Operating as a SUMO E3 Ligase for theTranscriptional Regulator SnoN1.
Ikeuchi Y, Dadakhujaev S, Chandhoke AS, Huynh MA, Oldenborg A, Ikeuchi M, Deng L, Bennett EJ, Harper JW, Bonni A, Bonni S.
J Biol Chem. 2014 Jul 24.
PMID: 25059663

Structural basis for translational surveillance by the large ribosomal subunit-associated protein quality control complex. 
Lyumkis D, Oliveira dos Passos D, Tahara EB, Webb K, Bennett EJ, Vinterbo S, Potter CS, Carragher B, Joazeiro CA.
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15981-6.
PMID: 25349383


A novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain.
Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A.
J Neurosci. 2013 Nov 13;33(46):18015-21.
PMID: 24227713

Multimodal mechanism of action for the Cdc34 acidic loop: a case study for why ubiquitin-conjugating enzymes have loops and tails.
Ziemba A, Hill S, Sandoval D, Webb K, Bennett EJ, Kleiger G.
J Biol Chem. 2013 Nov 29;288(48):34882-96
PMID: 24129577

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF(FBXL17) in NRF2 Activation via BACH1 Repressor Turnover. 
Tan MK, Lim HJ, Bennett EJ, Shi Y, Harper JW.
Mol Cell. 2013 Oct 10;52(1):9-24.
PMID: 24035498

The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain.
Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, Bonni A.
Neuron. 2013 Jun 19;78(6):986-93.
PMID: 23791194

Using the ubiquitin modified proteome to monitor protein homeostasis function. 
Carrano AC, Bennett EJ.
Mol Cell Proteomics. 2013 May 23. [Epub ahead of print]
PMID: 23704779

Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. 
Monda JK, Scott DC, Miller DJ, Lydeard J, King D, Harper JW, Bennett EJ, Schulman BA.
Structure. 2013 Jan 8;21(1):42-53.
PMID: 23201271

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA.
Mol Cell Biol. 2013 Apr;33(8):1487-502.
PMID: 23382074


Proteomics propels protein degradation studies in San Diego.
Bennett EJ, Mayor T.
Mol Cell Proteomics. 2012 Dec;11(12):1523-8.
PMID: 22798279


Systematic and quantitative assessment of the ubiquitin modified proteome.
Kim, W.,* Bennett, E.J.*, Huttlin, E.L., Guo, A., Li, J., Possemato, A., Sowa, M.E., Rad, R., Rush, J., Comb, M.J., Harper, J.W., and Gygi, S.P.
Molecular Cell 2011 Oct 21;44(2):325-40.
PMID: 21906983
* Authors contributed equally

N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex. 
Scott, D.C., Monda, J.K., Bennett, E.J., Harper, J.W., Schulman, B.A.
Science 2011 Nov 4;334(6056): 674-8.
PMID: 21940857

Defining human ERAD networks through an integrative mapping strategy.
Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Wade Harper J, Kopito RR.
Nat Cell Biol. 2011 Nov 27. doi: 10.1038/ncb2383.
PMID: 22119785


Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.
Bennett EJ, Bence NF, Jayakumar R, Kopito RR.
Molecular Cell 2005 Feb 4;17(3):351-365.
PMID: 15694337

Application and analysis of the GFPu family of ubiquitin-proteasome system reporters. 
Bence NF, Bennett EJ, Kopito RR.
Methods Enzymol. 2005;399:481-90.
PMID: 16338377

Global changes to the ubiquitin system in Huntington’s disease. 
Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR.
Nature 2007 Aug 9;448(7154):704-708.
PMID: 17687326

Defining the Human Deubiquitinating Enzyme Interaction Landscape. 
Sowa ME*, Bennett EJ*, Gygi SP, Harper JW.
Cell. 2009 Jul 23;138(2):389-403
*Authors contributed equally
PMID: 19615732


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